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Medicinal Chemistry

Nuclear Receptor Ligands

Toshihiko Tashima, Hiroyuki Kagechika, Motonori Tsuji, Hiroshi Fukasawa, Emiko Kawachi, Yuichi Hashimoto, and Koichi Shudo. Polyenylidene Thiazolidine Derivatives with Retinoidal Activities. Chem. Pharm. Bull., 1997, 45, 1805-1813.

Kiminori Ohta, Motonori Tsuji, Emiko Kawachi, Hiroshi Fukasawa, Yuichi Hashimoto, Koichi Shudo, and Hiroyuki Kagechika. Potent Retinoid Synergists with a Diphenylamine Skeleton. Biol. Pharm. Bull., 1998, 21, 544-546.

Toru Iijima, Yasuyuki Endo, Motonori Tsuji, Emiko Kawachi, Hiroyuki Kagechika, Koichi Shudo. Dicarba-closo-dodecaboranes as a Pharmacophore. Retinoidal Antagonists and Potential Agonists. Chem. Pharm. Bull., 1999, 47, 398-404.

Masayuki Ebisawa, Hiroki Umemiya, Kiminori Ohta, Hiroshi Fukasawa, Emiko Kawachi, Ghislaine Christoffel, Hinrich Gronemeyer, Motonori Tsuji, Yuichi Hashimoto, Koichi Shudo, and Hiroyuki Kagechika. Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids. Chem. Pharm. Bull.,1999, 47, 1778-1786.

Motonori Tsuji*, Koichi Shudo, Hiroyuki Kagechika. Docking Simulations Suggest that all-trans Retinoic Acid Could Bind to Retinoid X Receptors. J. Comput. Aided Mol. Des., 2015, 29, 975-988. 

Motonori Tsuji. A Ligand-Entry Surface of the Nuclear Receptor Superfamily Consists of the Helix H3 of the Ligand-Binding Domain. J. Mol. Graph. Model., 2015, 62, 262-275. 

Motonori Tsuji*, Koichi Shudo, Hiroyuki Kagechika. Identifying the Receptor Subtype Selectivity of Retinoid X and Retinoic Acid Receptors via Quantum Mechanics. FEBS Open Bio., 2017, DOI: 10.1002/2211-5463.12188.

Others

Motonori Tsuji, Yukiko Koiso, Hiroyasu Takahashi, Yuichi Hashimoto, and Yasuyuki Endo. Modulators of Tumor Necrosis Factor a Production Bearing Dicarba-closo-dodecaborane as a Hydrophobic Pharmacophore. Biol. Pharm. Bull., 2000, 23, 513-516.

 

Bioorganic Chemistry

Motonori Tsuji, Eiichi Kuwano, Tetsuya Saito, and Morifusa Eto. Root Growth-promoting Activities of N-Acyl-L-proline Derivatives. Biosci. Biotech. Biochem., 1992, 56, 778-782.

 

Molecular Modeling (Rational Drug Design)

Motonori Tsuji. Development of the Structure-based Drug Design Systems, HMHC and DSHC. Mol. Sci., 2007, 1, NP004.

 

Structural Biology

Motonori Tsuji. Local Motifs Involved in the Canonical Structure of the Ligand-Binding Domain in the Nuclear Receptor Superfamily. J. Struct. Biol., 2014, 185,355-365. 

 

Theoretical Organic Chemistry

Tomohiko Ohwada, Masanobu Uchiyama, Motonori Tsuji, Iwao Okamoto, and Koichi Shudo. Orbital Unsymmetrization of Olefins Arising from Non-equivalent Orbital Interactions. s-p Coupling in Bicyclo[2.2.2]octenes. Chem. Pharm. Bull., 1996, 44, 296-306.

Tomohiko Ohwada, Motonori Tsuji, Iwao Okamoto, and Koichi Shudo. A Remote Substituent Can Determine Magnitude of Facial Selectivity in Benzobicyclo[2.2.2]octatrienes. Tetrahedron Lett., 1996, 37, 2609-2612.

Motonori Tsuji, Tomohiko Ohwada, and Koichi Shudo. A cyclopropyl Group Shows Reverse Facial Selectivity Depending on the Bicyclic Ring System. Tetrahedron Lett., 1997, 38, 6693-6696.

Motonori Tsuji, Tomohiko Ohwada, and Koichi Shudo. Facial Selectivities of Benzofluorenes Bearing a Carbonyl, an Olefin, or a Diene Group in Spiro Geometry. p Spiro Substituent Effects. Tetrahedron Lett., 1998, 39, 403-406.

Motonori Tsuji. On Attempts at Generation of Carboranyl Carbocation. J. Org. Chem., 2003, 68, 9589-9597.

Motonori Tsuji. Most Stable Conformation of the Cyclopropane Ring Attached at a Carbon Atom in a 1,2-Dicarba-closo-dodecaborane(12) System. J. Org. Chem., 2004, 69, 4063-4074.

Motonori Tsuji. Geometrical Dependence of the Highest Occupied Molecular Orbital in Bicyclic Systems: p Facial Stereoselectivity of Bicyclic and Tricyclic Olefins. Asian J. Org. Chem.,2015, 4, 659-673. 

 

Inorganic Chemistry

Yasuyuki Endo, Kyoko Yaguchi, Motonori Tsuji, Kentaro Yamaguchi, and Koichi Shudo. Functionalization of Polymethylcarboranes. Preparation and Reactivity of 2,3,4,5,6,7,8,9,10,11-Decamethyl-1,12-dicarba-closo-dodecaborane(12)-1-carboxylic Acid. Chem. Pharm. Bull., 1999, 47, 699-701.