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Synthesis and Activity of Carboranamine Derivatives as an Anti-Influenza A Virus Active Compound


The adamanthylamine (Amantadine) and its derivative, Remantadine, show an anti-influenza A virus activity. The mechanism of this activity is considered as destruction of the virus cell membrane. The following figures show a typical anti-influenza A active compound.

Amantadine                                 Reamantadine

Influenza A virus active compounds


The following carboranamine derivatives were synthesized and their anti-influenza activity were estimated.




Unfortunately, all of these compounds did not show an anti-influenza virus activity.


From experimental notebook at 1998.

Motonori Tsuji




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