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   Last Modified

   3 July 2017

Theoretical Organic Chemistry Nuclear Receptor Chemistry Structural Bioinformatics Rational Drug Design

Nuclear Receptor Superfamily

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Nuclear Receptor

 

Structural Biology

Origin of the receptor subtype selectivity via quantum mechanics.

Motonori Tsuji, et. al. FEBS Open Bio. 7, 391-396, 2017, DOI: 10.1002/2211-5463.12188.

Receptor Subtype Selectivity via Quantum Mechanics 

Origin of the ligand recognition mechanism in the nuclear receptor superfamily.

Motonori Tsuji. J. Mol. Graph. Model. 62, 262-275, 2015.

Origin of the Ligand Recognition Mechanism 

 

Identifying the folding mechanism and the agonism and atagonism mechanism of the ligand-binding domain in the nuclear receptor superfamily.

Motonori Tsuji. J. Struct. Biol. 185, 355-365, 2014.

The folding mechanism and the agonism and atagonism mechanism of the ligand-binding domain in the nuclear receptor superfamily

 

Molecular Mechanism

Origin of the agonism and antagonism mechanisms in the nuclear receptors via quantum mechanics.

Motonori Tsuji. J. Comput. Aided Mol. Des. 31, 577-585, 2017, DOI: 10.1007/s10822-017-0025-6.

Antagonist AF-2 Fixed Motif Perturbation Mechanism

 

A proposed molecular mechanism of ATRA for retinoid X receptors.

Motonori Tsuji, et. al. J. Comput. Aided Mol. Des. 29, 975-988, 2015.

Novel Molecular Mechanism of ATRA Proposed Mechanism for RXR-RAR Heterodimer

 

Structure-based Drug Design

Motonori Tsuji. Logical Drug Design for Organic Chemists (Japanese)

Design of Retinoid X Receptor Agonist

Design of Human Retinoid X Receptor Agonists

 

Design of Human Retinoid X Receptor Antagonists

 

Homology Modeling

Human Androgen Receptor DNA Binding Domain

 

Human Mineralocorticoid Receptor Ligand Binding Domain

 

Crystal Structures

Freely access our database in which the nuclear hormone receptor crystal structures registered to the Protein Data Bank have been classified on the basis of the structural information.

   Analyzed Nuclear Receptor Crystal Structure Database

 

Physical Chemistry

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Theory

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Other Useful Information

   Nuclear Receptor (Journal)

   Nuclear Receptor Mutation Database

   Nuclear Receptor Database

 

 

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