Japanese

 

 

 

   Last Modified

   12 Nov 2014

Theoretical Organic Chemistry Nuclear Receptor Chemistry Structural Bioinformatics Rational Drug Design

Homology Modeling for HyperChem Logo Gaussian Interface for HyperChem Logo Full-Auto Interactive, Muti-layer ONIOM Interface Logo Docking Study with HyperChem Logo Mol Dimension Logo Virtual Screening System Technology The Next-generation Drug Design Technology

 

Announce

What's New in Revision F3.

 


Docking Study with HyperChem, Revision F3

- Carrying The Next-generation Drug Discovery Technology, The PIEFII Technology -

Docking Study with HyperChem, Revision F1

 

Powered by Docking Study with HyperChem   THE IMPOSSIBLE BECOMES POSSIBLE.

Advanced Technology & The High-Performance, Biomacromolecule- & Ligand-Flexible Docking & Screening Program Package

Docking Study with HyperChem supports the comprehensive and automatic biomacromolecule (protein and nucleic acid molecule systems)- and ligand (small molecule and peptide)-flexible docking simulations, and thus supports the drug design and the in silico screening of a drug candidate.


Homology Modeling Professional for HyperChem, Revision F3

with Gaussian Interface for HyperChem & ONIOM Interface for Receptor

 

Homology Modeling Professional for HyperChem, Revision F1

 

Powered by Homology Modeling for HyperChem   THE IMPOSSIBLE BECOMES POSSIBLE.

New, High-Performance Software for Protein Modeling, Functional Analysis, and Simulation.

Homology Modeling for HyperChem is the latest molecular modeling package which can carry out the molecular modeling, functional analysis, and simulations of a big molecular system using comprehensively the ab-initio quantum chemistry calculations and the molecular dynamics simulations as well as the molecular mechanics calculations. The program can control seamlessly both HyperChem and Gaussian packages and can be simultaneously fed back their calculation results to the big molecular system in the HyperChem graphical user interface. The whole molecular system can be operated in a quantum chemistry via the full-automatic ONIOM interface to Gaussian. All operations are fully automated in the GUI-based manner, and thus the program supports the logical molecular modeling, functional analysis, and simulations in the life science research such as the structure-based drug design, as well as an unexplored research.

 


 


                  The Next-generation Drug Discovery Technology

                                        PEIFII

                                     Ab-Initio Protein-Ligand Interaction Site

                        Structure-based Pharmacophore Prediction Technology

                                      Potential Ligand Prediction Technology

                                          A New Drug Design Methodology


 

 

Topics


2014/03/18   Our paper regarding the folding mechanism and the agonism and atagonism mechanism of the ligand-binding domain in the nuclear receptor superfamily using Homology Modeling Professional for HyperChem has recently been published in Journal of Structural biology (185, 355-365, 2014).

The folding mechanism and the agonism and atagonism mechanism of the ligand-binding domain in the nuclear receptor superfamily

 

2013/07/01   10th anniversary

2012/11/30   We have acquired patent rights regarding structural-based pharmacophre prediction technology.

2010/12         Homology Modeling Professional for HyperChem was cited in an article. Biochemistry. 2010 Dec; 49 (50): 10647-10655.

2010/04/30   Homology Modeling Professional for HyperChem was cited in an article. Biochemical and Biophysical Research Communications. 2010 Apr 30; 339 (2): 173-177.

2008/02         Docking Study with HyperChem and Homology Modeling Professional for HyperChem were cited in an article. Science. 2008 Feb 1; 319 (5863): 624-7.

2008/01/11   Motonori Tsuji was invited as a guest speaker at Business Research Institute.

2007/06/29   Docking Study with HyperChem and Homology Modeling Professional for HyperChem were introduced in an article. Molecular Science. 2007; 1: NP004.

2007/06/16   We really appreciate great cooperation of Neil S. Ostlund, President and Chief Executive Officer of Hypercube, Inc.

2005/08/09   Our products have been linked to the Gaussian Official site.


 

Latest News   Archives


2014/10/14   Announcing  Docking Study with HyperChem and Homology Modeling Professional for HyperChem, Revision F3.

2014/10/02   We were able to confirm that Docking Study with HyperChem and Homology Modeling Professional for HyperChem were compatible with Windows 10 Technical Preview (64 bit Version).

2014/03/18   Our paper regarding the folding mechanism and the agonism and atagonism mechanism of the ligand-binding domain in the nuclear receptor superfamily using Homology Modeling Professional for HyperChem has recently been published in Journal of Structural biology (185, 355-365, 2014).


 

* HyperChem is a registered trademark of Hypercube, Inc.

*" Gaussian is a registered trademark of Gaussian, Inc.

 

Site Map 

Copyright (C) 2004-2014 Institute of Molecular Function. All Rights Reserved.