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Last Modified 18 April 2016 |
The first success of the structural transition of the holo-form formation simulations and the discovery of the driving forces involved in the ligand entry in the nuclear receptor superfamily using Docking Study with HyperChem and Homology Modeling Professional for HyperChem has been accepted for publication. Motonori Tsuji, J. Mol. Graph. Model. 2015, 62, 262-275.
Core Technologies of Docking Study with HyperChem and Homology Modeling Professional for HyperChem have been accepted for publication in J. Comput. Aided Mol. Des. 2015, 29, 975-988.
Announce What's New in Revision G1. 2016 The function of ONIOM Interface is strengthened and available for calculating the whole system.
Docking Study with HyperChem, Revision G1 - Carrying The Next-generation Drug Discovery Technology, The PIEFII Technology -
Powered by Docking Study with HyperChem THE IMPOSSIBLE BECOMES POSSIBLE. Advanced Technology & The High-Performance, Biomacromolecule- & Ligand-Flexible Docking & Screening Program Package Docking Study with HyperChem supports the comprehensive and automatic biomacromolecule (protein and nucleic acid molecule systems)- and ligand (small molecule and peptide)-flexible docking simulations, and thus supports the drug design and the in silico screening of a drug candidate. Homology Modeling Professional for HyperChem, Revision G1 with Gaussian Interface for HyperChem & ONIOM Interface for Receptor
Powered by Homology Modeling for HyperChem THE IMPOSSIBLE BECOMES POSSIBLE. New, High-Performance Software for Protein Modeling, Functional Analysis, and Simulation. Homology Modeling for HyperChem is the latest molecular modeling package which can carry out the molecular modeling, functional analysis, and simulations of a big molecular system using comprehensively the ab-initio quantum chemistry calculations and the molecular dynamics simulations as well as the molecular mechanics calculations. The program can control seamlessly both HyperChem and Gaussian packages and can be simultaneously fed back their calculation results to the big molecular system in the HyperChem graphical user interface. The whole molecular system can be operated in a quantum chemistry via the full-automatic ONIOM interface to Gaussian. All operations are fully automated in the GUI-based manner, and thus the program supports the logical molecular modeling, functional analysis, and simulations in the life science research such as the structure-based drug design, as well as an unexplored research.
The Next-generation Drug Discovery Technology Ab-Initio Protein-Ligand Interaction Site Structure-based Pharmacophore Prediction Technology Potential Ligand Prediction Technology
Topics 2015/10/07 Origin of the ligand recognition mechanism in the nuclear receptor superfamily has been published in J. of Mol. Graph. Model. 62, 262-275, 2015. 2015/09/13 Hypothetical paper regarding new ATRA mechanisms via nuclear receptor (using core technologies of Docking Study with HyperChem and Homology Modeling Professional for HyperChem) has been accepted for publication in J. Comput. Aided Mol. Des. 2015, 29, 975-988. 2015/04/17 Discovery of the underlying rule for the facial stereoselectivity, which is the most important and unsolved issue in organic chemistry, has recently been accepted for publication in Asian Journal of Organic Chemistry.
2014/03/18 Our paper regarding the folding mechanism and the agonism and atagonism mechanism of the ligand-binding domain in the nuclear receptor superfamily using Homology Modeling Professional for HyperChem has recently been published in Journal of Structural biology (185, 355-365, 2014).
2013/07/01 10th Anniversary 2012/11/30 We have acquired patent rights regarding structural-based pharmacophre prediction technology. 2010/12 Homology Modeling Professional for HyperChem was cited in an article. Biochemistry. 2010 Dec; 49 (50): 10647-10655. 2010/04/30 Homology Modeling Professional for HyperChem was cited in an article. Biochemical and Biophysical Research Communications. 2010 Apr 30; 339 (2): 173-177. 2008/02 Docking Study with HyperChem and Homology Modeling Professional for HyperChem were cited in an article. Science. 2008 Feb 1; 319 (5863): 624-7. 2008/01/11 Motonori Tsuji was invited as a guest speaker at Business Research Institute. 2007/06/29 Docking Study with HyperChem and Homology Modeling Professional for HyperChem were introduced in an article. Molecular Science. 2007; 1: NP004. 2007/06/16 We really appreciate great cooperation of Neil S. Ostlund, President and Chief Executive Officer of Hypercube, Inc. 2005/08/09 Our products have been linked to the Gaussian Official site.
Latest News Archives 2016/04/16 We were able to confirm that ONIOM Interface for Receptor and Gaussian Interface for HyperChem were compatible with the latest Gaussian09W (64bit-multiprocessor version, Revision E.01) under support of Gaussian, Inc. We really appreciate great help of Gaussian, Inc. 2016/03/27 Motonori Tsuji spoke a research entitled "Geometrical Dependence of the Highest Occupied Molecular Orbital in Bicyclic Systems: Origin of the Facial Stereoselectivity of Bicyclic Olefins" at the 136th annual meeting of the pharmaceutical society of Japan. 2016/03/26 The function of ONIOM Interface for Receptor was strengthened (compatible to whole system of protein and nucleic acid molecular system). 2015/12/01 We were able to confirm that Docking Study with HyperChem and Homology Modeling Professional for HyperChem were compatible with Windows 10 Professional (64 bit Version). 2015/11/04 Origin of the ligand recognition mechanism in the nuclear receptor superfamily has been published in J. of Mol. Graph. Model. 62, 262-275, 2015. 2015/10/07 The first success of the structural transition of the holo-form formation simulations and the discovery of the driving forces involved in the ligand entry in the nuclear receptor superfamily using Docking Study with HyperChem and Homology Modeling Professional for HyperChem has been accepted for publication. 2015/09/13 Hypothetical paper regarding new ATRA mechanisms via nuclear receptor (using core technologies of Docking Study with HyperChem and Homology Modeling Professional for HyperChem) has been accepted for publication in J. Comput. Aided Mol. Des. 29, 975-988, 2015. 2015/04/17 Discovery of the underlying rule for the facial stereoselectivity, which is the most important and unsolved issue in organic chemistry, has recently been accepted for publication in Asian Journal of Organic Chemistry. 2015/03/26 Motonori Tsuji spoke a research entitled "Structure and function of the local motifs in the canonical structure of the ligand-binding domain in the nuclear receptor superfamily" at the 135th annual meeting of the pharmaceutical society of Japan. 2015/01/04 Announcing Docking Study with HyperChem 2015 and Homology Modeling Professional for HyperChem 2015, Revision G1. 2014/10/14 Announcing Docking Study with HyperChem and Homology Modeling Professional for HyperChem, Revision F3. 2014/10/02 We were able to confirm that Docking Study with HyperChem and Homology Modeling Professional for HyperChem were compatible with Windows 10 Technical Preview (64 bit Version). 2014/03/18 Our paper regarding the folding mechanism and the agonism and atagonism mechanism of the ligand-binding domain in the nuclear receptor superfamily using Homology Modeling Professional for HyperChem has recently been published in J. Struct. biol. 185, 355-365, 2014.
* HyperChem is a registered trademark of Hypercube, Inc. *" Gaussian is a registered trademark of Gaussian, Inc.
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